Psychological breast growth-Impact of lifestyle and psychological stress on the development of early onset breast cancer

To investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors. We investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. Another group of women with breast cancer, but with no previous history of chronic psychological stress, comprised the Control Group. Clinical and pathological data were assessed. Women presenting with a history of chronic distress were significantly overweight when compared to the Control Group.

Psychological breast growth

The breast growth can occur over the course of a few years, but there have been some cases of gigantomastia where Psychological breast growth woman's breasts grew Psychological breast growth or more cup sizes within a few days. BMC Cancer ; 4 —8. Discussion The present study is a case—control study of the risk factors associated with early onset breast cancer in China. Greast Causes Control ; 23 —9. We employed this approach aiming to compare the impact of chronic emotional distress on clinical and pathological characteristics of breast tumors, in both groups. To reach this goal we initially applied the SRQ as a psychiatric screening tool to compose the stress cohort.

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Gigantomastia is a rare condition that causes excessive growth of the female breasts.

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To investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors. We investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. Another group of women with breast cancer, but with no previous history of chronic psychological stress, comprised the Control Group.

Clinical and pathological data were assessed. Women presenting with a history of chronic distress were significantly overweight when compared to the Control Group. Furthermore, it was observed that these stressed women also had a significant percentage of aggressive breast cancer subtype, the HER2 amplified tumor, which could be putatively associated with the loss of immunosurveillance. Our findings suggested an interaction among chronic psychological stress, overweight, and the development of more aggressive breast tumors.

Breast cancer is a multifactorial disease, consisting of a public health problem worldwide. Some factors that interact among themselves contribute to the high incidence of breast cancer, including family history, presence of high-susceptibility genes, excessive body weight, and chronic stress. In this context, chronic psychological stress is a common finding reported by cancer patients.

Stressful life events are considered important components that can affect the emotional state of the individuals, and their association with loss of social support is even related to significantly shortened survival in breast cancer patients.

Concerning the biological impact of chronic distress, the sustained psychological stress alone can lead to weight gain through several biological mechanisms, 2 which may potentially result in loss of immunosurveillance. Although the relation between cancer development and chronic stress has been described, little is known concerning the impact of chronic psychological stress in the phenotype of breast tumors.

To clarify this question, we investigated if women presenting with chronic emotional distress could exhibit more aggressive phenotypes of breast cancer. To investigate clinicopathological findings from women diagnosed with breast cancer, and study the impact of chronic psychological stress in the pathological characteristics of tumors. They had been previously scheduled to undergo chemotherapy on a set day of the week, the same period. The inclusion criteria adopted were women with infiltrative ductal carcinoma of breast, uni- or bilateral, diagnosed between August and July , eligible according to the Self-Reporting Questionnaire SRQ as stress or non-stress cohorts.

Considering that 1 our population was approximately thousand inhabitants; 2 a p value of 0. Taking into account the period of the study and the fact that we worked with patients previously scheduled on a fixed day of the week to undergo chemotherapy, we decided to include 17 patients in each group.

In this context, this study enrolled 34 women diagnosed with infiltrative ductal carcinoma of the breast.

This study was previously approved by the Institutional Review Board, and all participants signed the Informed Consent Form. Clinical records were assessed and the data collected included age at diagnosis, weight, height, comorbidities, TNM classification, and chemotherapy regimen.

For determining the chronic psychological stress status of patients, we conducted an initial interview to verify the social support of the patient family income, type of residence, level of education, life style, and social relationships , since we did not know if the patients were from different social conditions.

Because all patients reported similar socioeconomic data, we continued the study by applying the SRQ for psychiatric disorder screening. Formalin-fixed, paraffin-embedded samples from tumor biopsies were immunostained with primary antibodies for estrogen receptor ER; anti-human estrogen receptor alpha, clone 1D5 at ; Dako, Dinamarca , progesterone receptor PR; anti-human progesterone, clone PGR at ; Dako, Dinamarca , and human epidermal growth receptor 2 HER-2, anti-human HER2-pY, clone PN2A at ; Dako, Dinamarca , in association with a commercial immunohistochemistry kit.

Samples were scored and categorized. All data were compared by using the non-parametric Mann-Whitney test. All statistical analyses were performed using the GraphPad Prism software version 5. The mean age at diagnosis was The most common traumas related were death of family members, abandonment by a partner, employment loss, sexual abuse, and major depression. The patients who reported a positive history of psychological stress were categorized to form the Stress Group.

Aiming to understand the clinicopathological impact of chronic psychological stress on breast cancer and clinical features, we compared the data from the Stress Group with a control cohort, composed of women diagnosed with breast cancer with no past history of chronic emotional stress.

For the last years, breast cancer has been the leading malignant neoplasm in women worldwide. This fact deserves attention, since the list of risk factors related with this disease is growing. Our aim was to investigate women diagnosed with breast cancer who reported a past history of chronic psychological stress and its impact on clinicopathological aspects of breast cancer. To reach this goal we initially applied the SRQ as a psychiatric screening tool to compose the stress cohort.

It detects symptoms, such as anxiety, depression, and psychosomatic complaints with adequate accuracy. We further selected another cohort of patients who had a similar clinical history age at diagnosis, family history, general health status, and family income , but with no prior report of chronic psychological stress to compose the Control Group.

We employed this approach aiming to compare the impact of chronic emotional distress on clinical and pathological characteristics of breast tumors, in both groups.

Our data indicated that a significant portion of the women enrolled in the Stress Group were overweight when compared to those of the Control Group. Both psychological stress and overweight are important risk factors for breast cancer development.

Overweight increases the risk for breast cancer recurrence after the primary tumor excision, and significantly reduces the overall survival of patients 13 by affecting the spreading of breast cancer cells.

It is well-established that chronic inflammation induced by the excessive availability of lipids found during overweight and obesity conditions can promote cancer spreading and aggressiveness, a process mediated by tumor-driven cytokines.

Based on this hypothesis, we investigated the phenotypic profile of breast tumors in both groups. Our data revealed that women with a history of psychological stress displayed a significant percentage of tumors overexpressing HER2. HER2-amplified breast tumors promote aggressive disease, with poor prognosis 14 - 16 due to its rapid proliferation and spreading.

We further observed that most patients presented with the HER2-amplified tumor mass located in the left breast. The left mammary gland frequently presents more breast tissue than the right, which may benefit fat accumulation and cancer development.

These data support the hypothesis that the women enrolled in the present study have a complex chain formed by historical factors of psychological stress, overweight, and development of phenotypically aggressive breast tumors. The main limitations of our study included the small sample size and the need for a long-term follow-up of patients to examine the recurrence of the disease and responsiveness to chemotherapy. Our data suggest that chronic psychological stress may represent a considerable risk factor for weight gain and development of aggressive tumors in women diagnosed with breast cancer, such as human epidermal growth factor receptor 2-amplified breast tumors.

National Center for Biotechnology Information , U. Journal List Einstein Sao Paulo v. Einstein Sao Paulo. Find articles by Thayse Fachin Cormanique. Find articles by Cynthia Alba Rech. Find articles by Daniel Rech. Find articles by Carolina Panis. Author information Article notes Copyright and License information Disclaimer. Received Mar 1; Accepted Aug Copyright notice. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article has been cited by other articles in PMC. Abstract Objective To investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors. Methods We investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. Results Women presenting with a history of chronic distress were significantly overweight when compared to the Control Group.

Conclusion Our findings suggested an interaction among chronic psychological stress, overweight, and the development of more aggressive breast tumors. OBJECTIVE To investigate clinicopathological findings from women diagnosed with breast cancer, and study the impact of chronic psychological stress in the pathological characteristics of tumors.

Molecular subtyping of breast tumors by immunohistochemistry Formalin-fixed, paraffin-embedded samples from tumor biopsies were immunostained with primary antibodies for estrogen receptor ER; anti-human estrogen receptor alpha, clone 1D5 at ; Dako, Dinamarca , progesterone receptor PR; anti-human progesterone, clone PGR at ; Dako, Dinamarca , and human epidermal growth receptor 2 HER-2, anti-human HER2-pY, clone PN2A at ; Dako, Dinamarca , in association with a commercial immunohistochemistry kit.

Table 1 Main parameters employed for chronic psychological stress characterization. Open in a separate window. Figure 1. Analysis of body mass indexes.

Figure 2. Molecular subtyping of tumors. Influence of physical activity and nutrition on obesity-related immune function; Review. Sominski L, Spencer SJ.

Eating behavior and stress: a pathway to obesity. Front Psychol. Rev Bras Cancerol. Loss of a parent and the risk of cancer in early life: a nationwide cohort study. Cancer Causes Control. What causes breast cancer? A systematic review of causal attributions among breast cancer survivors and how these compare to expert-endorsed risk factors.

Impaired natural killer cell lysis in breast cancer patients with high levels of psychological stress is associated with altered expression of killer immunoglobulin-like receptors. J Surg Res. Obesity increases the incidence of distant metastases in oestrogen receptor-negative human epidermal growth factor receptor 2-positive breast cancer patients.

Eur J Cancer. Mari JJ, Williams P. Br J Psychiatry. Tumour Biol. Sartorius N, Janca A. Psychiatric assessment instruments developed by the World Health Organization. Soc Psychiatry Psychiatric Epidemiol. Chance of psychiatric morbidity amongst recently diagnosed cancer outpatients attending a chemotherapy unit.

Braz J Med Biol Res. Overweight and obesity as poor prognostic factors in locally advanced breast cancer patients. Breast Cancer Res Treat. Impact of the obesity on lymph node status in operable breast cancer patients.

Arch Dis Child. Finally, I find it ironic that the probiotic foods that health-conscious consumers and companies are advocating like yogurt first remove the probiotics via pasteurization while leaving dead bacteria in the product then artificially add some probiotics back in for health - all the while charging a hefty premium for something that is already in milk naturally. It is necessary to research all your unique surgical and non-surgical options on the subject of breast augmentation. Committees of Interest. Psychological stress describes what people feel when they are under mental, physical, or emotional pressure.

Psychological breast growth

Psychological breast growth

Psychological breast growth

Psychological breast growth. Important Factor for Determining Bovine Ovary Quality

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Gynecomastia also spelled Gynaecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs. The development of gynecomastia is usually associated with benign pubertal changes.

The condition commonly resolves on its own and conservative management of gynecomastia is often all that is necessary. Medical treatment of gynecomastia that has persisted beyond two years is often ineffective. Medications such as aromatase inhibitors have been found to be effective in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz—Jeghers syndrome , [8] but surgical removal of the excess tissue is usually required.

Gynecomastia is common. Adolescent males often have temporary gynecomastia due to hormonal changes during puberty. The classic feature of gynecomastia is male breast enlargement with soft, compressible, and mobile subcutaneous chest tissue palpated under the areola of the nipple in contrast to softer fatty tissue.

Males with gynecomastia may appear anxious or stressed due to concerns about the possibility of having breast cancer. Gynecomastia is thought to be caused by an altered ratio of estrogens to androgens mediated by an increase in estrogen production, a decrease in androgen production, or a combination of these two factors. Certain health problems in men such as liver disease, kidney failure, or low testosterone can cause breast growth in men.

Drugs and liver disease are the most common cause in adults. Many newborn infants of both sexes show breast development at birth or in the first weeks of life. Gynecomastia in adolescents usually starts between the ages of 10 and 12 and commonly goes away after 18 months.

Declining testosterone levels and an increase in the level of subcutaneous fatty tissue seen as part of the normal aging process can lead to gynecomastia in older men. This is also known as senile gynecomastia. When the human body is deprived of adequate nutrition , testosterone levels drop, while the adrenal glands continue to produce estrogens, thereby causing a hormonal imbalance. A small proportion of male gynecomastia cases may be seen with rare inherited disorders such as spinal and bulbar muscular atrophy and the very rare aromatase excess syndrome.

Medications that are probably associated with gynecomastia include calcium channel blockers such as verapamil , amlodipine , and nifedipine ; risperidone , olanzapine , anabolic steroids , [9] [29] alcohol , opioids , efavirenz , alkylating agents , and omeprazole. People with kidney failure are often malnourished, which may contribute to gynecomastia development.

Dialysis may attenuate malnutrition of kidney failure. Additionally, many kidney failure patients experience a hormonal imbalance due to the suppression of testosterone production and testicular damage from high levels of urea also known as uremia-associated hypogonadism. In individuals with liver failure or cirrhosis, the liver's ability to properly metabolize hormones such as estrogen may be impaired. Additionally, those with alcoholic liver disease are further put at risk for development of gynecomastia; ethanol may directly disrupt the synthesis of testosterone and the presence of phytoestrogens in alcoholic drinks may also contribute to a higher estrogen to testosterone ratio.

Testicular tumors such as Leydig cell tumors or Sertoli cell tumors [33] such as in Peutz—Jeghers syndrome [4] or hCG -secreting choriocarcinoma [30] may result in gynecomastia. Other tumors such as adrenal tumors , pituitary gland tumors such as a prolactinoma , or lung cancer , can produce hormones that alter the male—female hormone balance and cause gynecomastia. Individuals with prostate cancer who are treated with androgen deprivation therapy may experience gynecomastia.

The causes of common gynecomastia remain uncertain, but are thought to result from an imbalance between the actions of estrogen and androgens at the breast tissue. Primary hypogonadism indicating an intrinsic problem with the testes in males leads to decreased testosterone synthesis and increased conversion of testosterone to estradiol potentially leading to a gynecomastic appearance. Individuals who have cirrhosis or chronic liver disease may develop gynecomastia for several reasons.

Cirrhotics tend to have increased secretion of the androgenic hormone androstenedione from the adrenal glands, increased conversion of this hormone into various types of estrogen, [6] and increased levels of SHBG, which leads to decreased blood levels of free testosterone.

Proper treatment of the hyperthyroidism can lead to the resolution of the gynecomastia. Medications are known to cause gynecomastia through several different mechanisms. These mechanisms include increasing estrogen levels, mimicking estrogen, decreasing levels of testosterone or other androgens, blocking androgen receptors, increasing prolactin levels, or through unidentified means.

To diagnose gynecomastia, a thorough history and physical examination are obtained by a physician. Important aspects of the physical examination include evaluation of the male breast tissue with palpation to evaluate for breast cancer and pseudogynecomastia male breast tissue enlargement solely due to excess fatty tissue , evaluation of penile size and development, evaluation of testicular development and an assessment for masses that raise suspicion for testicular cancer , and proper development of secondary sex characteristics such as the amount and distribution of pubic and underarm hair.

A review of the medications or illegal substances an individual takes may reveal the cause of gynecomastia. High levels of prolactin are uncommon in people with gynecomastia.

If this evaluation does not reveal the cause of gynecomastia, then it is considered to be idiopathic gynecomastia of unclear cause. Other causes of male breast enlargement such as mastitis , [14] [36] breast cancer , pseudogynecomastia, lipoma , sebaceous cyst , dermoid cyst , hematoma , metastasis , ductal ectasia , fat necrosis , or a hamartoma are typically excluded before making the diagnosis.

Mammography is the method of choice for radiologic examination of male breast tissue in the diagnosis of gynecomastia when breast cancer is suspected on physical examination. Early histological features expected to be seen on examination of gynecomastic tissue attained by fine-needle aspiration biopsy include the following: proliferation and lengthening of the ducts, an increase in connective tissue, an increase in inflammation and swelling surrounding the ducts, and an increase in fibroblasts in the connective tissue.

The utility of pathologic examination of breast tissue removed from male adolescent gynecomastia patients has recently been questioned due to the rarity of breast cancer in this population.

The spectrum of gynecomastia severity has been categorized into a grading system: [38]. Mild cases of gynecomastia in adolescence may be treated with advice on lifestyle habits such as proper diet and exercise with reassurance. In more severe cases, medical treatment may be tried including surgical intervention.

Medical treatment of gynecomastia is most effective when done within the first two years after the start of male breast enlargement. A few cases of gynecomastia caused by the rare disorders aromatase excess syndrome and Peutz—Jeghers syndrome have responded to treatment with AIs such as anastrozole. If chronic gynecomastia is untreated, surgical removal of glandular breast tissue is usually required.

Complications of mastectomy may include hematoma , surgical wound infection, breast asymmetry, changes in sensation in the breast, necrosis of the areola or nipple, seroma , noticeable or painful scars, and contour deformities.

Radiation therapy and tamoxifen have been shown to help prevent gynecomastia and breast pain from developing in prostate cancer patients who will be receiving androgen deprivation therapy. The efficacy of these treatments is limited once gynecomastia has occurred and are therefore most effective when used prophylactically. In the United States , many insurance companies deny coverage for surgery for gynecomastia treatment or male breast reduction on the basis that it is a cosmetic procedure.

Gynecomastia is not physically harmful, but in some cases it may be an indicator of other more serious underlying conditions, such as testicular cancer. Furthermore, gynecomastia frequently presents social and psychological difficulties such as low self-esteem or shame for the sufferer. Massive weight loss can result in sagging chest tissue known as chest ptosis. Gynecomastia is the most common benign disorder of the male breast tissue.

The prevalence of gynecomastia in men may have increased in recent years, but the epidemiology of the disorder is not fully understood. In , there were 14, procedures of this type performed in the United States alone. Gynecomastia can result in psychological distress for those with the condition. Common slang or derogatory terms for gynecomastia include man boobs or moobs. From Wikipedia, the free encyclopedia. Retrieved 20 January Merriam-Webster Dictionary.

American Journal of Roentgenology. Nat Rev Endocrinol. Mayo Clinic Proceedings. Nature Reviews. Expert Opinion on Drug Safety. The American Journal of Medicine Review. J Plast Reconstr Aesthet Surg. Indian J Endocrinol Metab. American Family Physician. Mayo Clinic internal medicine board review 9th ed. Medline Plus. US National Library of Medicine. Retrieved 15 November Reinforcing the evidence suggesting that there is a relationship between chemicals and GM, it is worthwhile mentioning the epidemic onset observed among Haitian refugees in about four months after arrival in United States detention centers.

Brody MD; D. Lynn Loriaux MD Endocrine Practice. Textbook of pediatric emergency medicine 6th ed. Williams Textbook of Endocrinology: Expert Consult. Chapter Neurologic Clinics. Pediatric Endocrinology Reviews. Indian Journal of Endocrinology and Metabolism. Journal of Cancer Research and Clinical Oncology. Ann Pharmacother. Patients with pre-existing gynecomastia as a result of previous endocrine therapy with estrogens sustained no worsening of their gynecomastia and may have improved symptomatically.

Cochrane Database of Systematic Reviews. Indian Journal of Pharmacology. European Journal of Endocrinology. Journal of Nephrology. Current Opinion in Pediatrics. The Journal of Urology. Archived from the original on 16 November Mayo Clinic. Retrieved 3 February

Psychological breast growth

Psychological breast growth